What is Etizolam?
Etizolam is primarily a thienodiazepine derivative that behaves like a benzodiazepine analog. It has anxiolytic and sedative properties than that of Benzodiazepines but with less tolerance and addiction potential.
Apart from anxiolytic and sedative, Etizolam even has hypnotic, anticonvulsant, amnesic and skeletomuscular relaxant properties. It was patented in 1972 and approved for medical use in 1983.
What is Etizolam used for?
Etizolam is used in the short term treatment of insomnia, a sleep disorder resulting in people having disturbed sleep at night.
It is used either on its own or in combination with other medications for the treatment of psychological factors like major depressive disorders, social anxiety, depression and panic disorders.
Studies have even found that it is highly effective for obsessive compulsive disorders.
Off label, it has been found to be effective for cervical spondylitis and lumbar pain as well as in pain associated with cancerous disorder.
How does Etizolam work?
Etizolam works by binding itself to the GABA receptors in the central nervous system. Their inhibition of the GABA pathway leads to increase in GABAergic transmission that in turn enhances GABA induced Chloride currents.
This helps in relaxing the activated nerve pathways and in turn treats anxiety, seizures and convulsions. Etizolam also exerts its binding effect on the alpha and gamma units to help in treatment of insomnia.
How long does it take to kick in?
This oral medicine has a good absorption rate in the gastrointestinal system. Post ingestion, it attaches itself quickly to the receptors but does not cross the blood brain barrier to result in any adverse effects. It takes Etizolam around 30 minutes to kick in. Once there it reaches peak plasma levels 30 minutes to 2 hours after ingestion. Take the medicine on an empty stomach with ample water to ensure faster absorption.
How long does Etizolam last?
Etizolam has a plasma half-life of 3.5 hours. Its active metabolite alpha-hydroxyetizolam has a half-life of over 8 hours. The lasting of Etizolam depends on the strength of the medication with systemic conditions.
But in general, the effects of Etizolam reach their peak in 3-4 hours and last in the system for next 6-8 hours. After this time period, it is metabolized by the liver and excreted through the kidneys in the form of urine and feces.
What is the dosage of Etizolam?
Etizolam is available in strengths of 0.5mg, 1mg, 2mg and 5mg. The dosage of the medication depends on its strength. Usually, tablets of 0.5mg-0.25mg are prescribed thrice daily for a maximum duration of 12 weeks.
For insomnia, 1mg-2mg is advised once daily. For panic disorders, 0.5mg of the tablet is taken twice daily. For anxiety disorders, 0.25mg- 0.5mg is advised twice daily with the total dose not exceeding 3 mg per day.
Etizolam vs. Xanax – which is better?
Both Xanax and Etizolam are used for the treatment of anxiety and insomnia. While Xanax is actually a benzodiazepine, Etizolam is a benzodiazepine analogue. Etizolam exhibits the properties of Benzodiazepines but is actually a Thienodiazepine. Etizolam is available in Japan, India and a few other countries but not legal in the USA. Xanax has been approved by the USA and is a common anxiolytic used there.
What is Etizolam 1mg legal status in Australia?
Being a benzodiazepine analogue, you can buy Etizolam in Australia only through a prescription. It is used mainly for sleep problems and anxiety disorders. It has been declared a Schedule IV medication meaning there is a low incidence of addiction associated with the medication and should be dispensed only by prescription.
Can I Order Etizolm Online in Australia?
Yes, you can order from Nootraplus Pharmacy.
Is Etizolam Harmful?
No. But can cause a toxic and fatal arrhythmia if you combined with other medications.
What are the things to remember before you buy Etizolam online In Australia?
While buying Etizolam online in Australia, it is important to remember that
- Etizolam comes in different colors- Etizolam 1mg tablets are dark blue in color and come in foil strips, Etizolam 2mg tablets come in a pink shade.
- It is important to buy it from a genuine pharmacy like Nootraplus.
- Avoid using tablets if you notice any sign of tampering or pilferage on the parcel. If the tablets look damaged or yellowed, do not use them.
Are there any contraindications of using Etizolam?
Etizolam being metabolized by the liver, it should not be used in people with hepatic impairments or liver infections. It should be used in caution in pregnant or breastfeeding ladies for safeguarding the fetus and the brain development of the infant. Etizolam can produce sleepiness.
Do not drive or operate heavy machinery after using it. People with a history of sleep apnea and myasthenia gravis should avoid Etizolam. Patients with psychotic disorder and benzodiazepine or alcohol addiction should not use Etizolam. Additionally, do not use the medication if you are allergic to it.
What are the side-effects associated with Etizolam?
Nausea, vomiting, headaches, dry mouth and decreased appetite are some of the common side effects associated with Etizolam use. Apart from these, prolonged use of Etizolam can also lead to respiratory depression, blurred vision, constricted pupils and decreased heart rate. Rebound insomnia cases have also been known to occur. Additionally, mental confusion and short term memory loss are some other side-effects associated with this Medication.
What are the drug interactions of Etizolam with Anticoagulants?
1mg of Etizolam when combined with Anticoagulants can lead to decrease in its metabolism. This can leads to its overdose in the system.
What are the drug interactions of Etizolam with Antipsychotics?
The risk and the severity of side effects associated with either medication increases when combined together.
What are the drug interactions of Etizolam with anticholinergic medications?
Etizolam when combined with anticholinergic medication causes it to increase the CNS (Central Nervous System) depressive activities of the medication.
What are the drug interactions of Etizolam with antihistamines?
Etizolam when combined with Antihistamines can lead to increase in the sedative activities of the medication.
What are the drug interactions of Etizolam with antifungal meds?
Etizolam 1mg Online when combined with antifungal drugs results in slow metabolism of Etizolam. This results in it building up in the body and causing overdose effects.
What are the drug interactions of Etizolam with alcohol?
Etizolam being a benzodiazepine analogue, when combined with alcohol it may lead to decreased mental and motor function. The results of the interaction between the two are usually depression, feelings of drowsiness, confusion and loss of coordination.